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Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)
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Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)
Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)
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Bone Marrow Hematopoiesis
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Immune Cells in the Tumor Microenvironment II
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Late-breaking: Tumor Immunology: Cellular Responses and Tumor Microenvironment
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Modulation of Immunity through Cytokines and Receptors
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T Cells in Cancer I
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T Cells in Cancer II
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Tumor and Immune Cell Crosstalk
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(731) PI3K Delta Inhibition Alters CD8 T Cell Différentiation and Reprograms the Tumor Microenvironment Following Adoptive Immunotherapy
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(732) Cancer cell-derived extracellular factors create distinct local TME niches in PDAC
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(733) Extracellular S100A9 Promotes CD8 T Cell Dysfunction and Suppression in the Pediatric Acute Myeloid Leukemia Tumor Microenvironment
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(734) CD25 expressed on keratinocytes sustains CD8+ T cell homeostasis and promotes anti-tumor responses
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(735) Differential Expression of Immunomodulatory Markers in the Tumor Microenvironment of High-Grade Gliomas
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(736) Cancer Cell Mediated Mitochondrial Transfer Reprograms Macrophage Metabolism and Polarization
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(738) Genetic linkage analysis identifies SNX3 as a regulator of antigen cross-presentation during anti-tumor antibody therapy
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(739) Spatial Multi-Platform Integration Reveals Distinct Tumor States and Microenvironmental Niches in Colitis-Associated Colorectal Cancer
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(741) Immune Cells in the Tumor Microenvironment I
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(743) Serotonin receptor HTR2B signalling modulates adaptive immune response to colon cancer and metastasis
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(744) T cell mediated dysregulation of bone marrow hematopoiesis in Glioblastoma
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(745) 35-color CytoFLEX mosaic panel profiling B cells, myeloid cells, and diagnostic markers in chronic lymphocytic leukemia (CLL)
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(747) FXR-Driven Macrophage Reprogramming Enhances Tumor Immunity and Limits Colorectal Cancer Growth
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(748) Characterizing the importance of the interaction between complement component C1q and the tumor microenvironment in colorectal cancer
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(749) Desmoplasia: a possible immunosuppressive microenvironment in colorectal cancer
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(750) Mirtron Overexpression Drives Immune Modulation and Tumor Progression Through Macrophage Polarization and Oncogenic Pathway Regulation
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(751) Potential Roles of Mirtron-5010 in Tumor Stemness and Immune Regulation
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(752) Quantifying the dual effect of anti-tumor and pro-tumor human neutrophils on natural killer cell behaviors in a microphysiological system
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(753) Tissue control of B-cell fate, antibody diversification, and isotype architecture – from metabolic disease to cancer
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(756) Defining the role of continued antigen engagement in regulating tumor-specific CD8+ T cell differentiation, migration, and survival.
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(757) Neoantigen-specific CD4+ T cells sustain endogenous intratumoral B cell responses to enhance anti-tumor immunity
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(759) IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells
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(760) Enhance Anti-Tumor Immunity by CD004-induced Reprogramming of IL-17-Producing CD8⁺ T Cells Toward Cytotoxic Tc1-Like Phenotypes
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(761) Dual protein phosphatase promotes effector CD8+ T-cell persistence and tumor control
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(761) Interrogating immune niches in a murine GBM model under radiation therapy
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(761) Macrophage migration inhibitory factor as a microbial modulator of colitis-associated colorectal cancer
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(762) Epigenetic Tumor Suppressor KMT2D Shapes the Immune Landscape in Pancreatic Cancer
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(762) Gut microbiota modulation potentiates anti-tumor immunity and immunotherapy in hepatocellular carcinoma
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(762) The pre-metastatic niche influences neutrophil behaviour, allowing cancer cells to hide in plain site
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(763) Double-Negative T Cells Induce Ferroptosis-Dependent, MHC-Independent Cytotoxicity of CD8⁺ T Cells Against AML
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(763) Mechanistic insights into cordycepin-enhanced CTLA-4 blockade efficacy via Eubacterium rectale-mediated immunomodulation in colon cancer
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(763) The Prevalence and Significance of Established Cancer Stem Cell Biomarkers in Follicular Lymphoma Patients
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(764) Development of a novel preclinical immunocompetent model of glioblastoma that reflects tumor heterogeneity
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(764) Novel autochthonous cancer model to investigate TCR signal strength in tumor-specific T cell differentiation
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(764) Pannexin-1 promotes CD8+ T cell antitumor immunity against colorectal cancer in a gender-dependent way
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(765) Immunotherapy Resistant Triple Negative Breast Cancer Utilizes Interferon Gamma Signaling to Evade NK Responses during Metastasis
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(765) IRF2 deletion in regulatory T cells enhances anti-viral and anti-tumor immune responses
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(765) Targeting SERPINA3 in Gliomas Extends Survival and Reprograms the Immune Landscape
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(766) Deciphering Translational Insights from Mouse Model to Human Tumors Using Imaging Mass Cytometry
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(766) Dynamic Gene Expression and Immune Cell Remodeling in DN T Cell-Mediated Antitumor Response to Breast Cancer
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(766) Suppression of IFN-g expression in Treg cells is dependent on the TCR signaling pathway
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(767) Codifying the Immune Landscape of Breast Cancer: A Morphology Driven Approach
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(767) Colon-Specific Signatures for Tissue Resident Memory T cells in Health and Colorectal Cancer
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(767) Integrated Multi-Omic Approach Using Spatial Transcriptomics and Proteomics Reveals an In-Depth View of Localized Immune Response in Renal Cancer
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(768) A Glucocorticoid-Fas axis controls immune evasion from pan-cytotoxic lymphocytes during metastatic seeding
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(768) Metformin modulates macrophage response to conditioned medium collected from triple-negative breast cancer cells
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(768) Regulatory T cells control anti-tumor microglia function in breast cancer brain metastasis
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(769) Bacteria Ammoniphilus Associated with High Tertiary Lymphoid Structures in Lung Squamous Cell Carcinoma
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(769) Impaired IFNγ transcription and translation drive tumor-specific CD8 T cell dysfunction
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(769) PTHrP is a novel mediator of immune suppression in pancreatic cancer
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(770) Loss of EOMES in T Cells Accelerates Tumor Burden and Mortality in Middle Aged Mice
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(770) Spatially Resolved High-Plex Protein Profiling of Immune States in FFPE Tissue
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(770) ST8SIA4-mediated polysialylation promotes CD8+ T cell infiltration in melanoma
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(771) Leveraging the adaptive NKG2C-HLA-E axis using neural network identified peptides for HER2-targeted NK cell immunotherapy
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(771) Sirt2-Mediated Deacetylation of Lck Regulates the Strength of T Cell Receptor Signaling
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(771) When gut stem cells talk to the immune system: impacts on remote tumor
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(772) Therapeutic Targeting of the IL-22/IL-22Rα Axis to Suppress Tumor Proliferation in Gynecologic Cancers
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(772) Transcriptional regulation of CD91 expression in antigen presenting cells and its impact on immune responses and disease
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(773) Investigating Cytotoxic Function in CD4+ T-cells for Cancer Immunotherapy
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(773) Modulation of the immunogenic landscape in colorectal cancer by mitochondrial DNAJC15 protein
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(773) Pharmacological Disruption of Glioblastoma Extracellular Vesicle-Myeloid Cell Interactions Mitigates Tumor-Induced Immunosuppression
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(774) Fluorescence tracking reveals CD8 T cell recruitment from lymph nodes to irradiated tumors and early activation via type I interferon
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(774) Targeting the KRAS G12D mutant suppresses tumor growth in a syngeneic mouse cholangiocarcinoma model through activation of immune cells
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(775) Epigenetic and metabolic mechanisms of CD8 T cell resiliency in cancer
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(775) Targeting FOXP3 Isoforms disrupts Tregs suppression in Colorectal Cancer
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(775) TIRTL-sequencing to interrogate the clonal repertoire of CARpos and CARneg TILs post CAR T-cell therapy for pediatric solid tumors
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(776) Differential signaling through the PD-1 receptor allows for a distinct inhibitory signature and unique signal dichotomy between PD-L1 and PD-L2
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(776) Enhanced Antitumor Immunity by a Peptide Improving Mitochondrial Quality in Dendritic Cells
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(776) Ion channel expression of CD8+ T cells in various tumor patients
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(777) Factors governing CD8+ resident memory (Trm) cell retention and migration in tumors and draining lymph nodes
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(777) Moderating Regulatory T Cell Brakes in CAR T Cell Immunotherapy of Solid Tumors Through the CD4-CD28 Co-stimulation Axis
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(778) Chimeric Antigen Receptor-Glypican-3 T Cell Therapy CAR001 for Advanced Hepatocellular Carcinoma: a first-in-human, phase I Trial
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(778) Impact of SYK inhibition on the Ovarian Cancer Tumor Microenvironment
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(778) Reversing defective priming in tumor-bearing hosts to rescue CD8 T cell function
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(779) B cells induce the age-related accumulation of CD39+CD73+ CD8+ T cells
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(779) Defining How Iron Metabolism and Cycling Shape the Immune Microenvironment in Synovial Sarcoma
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(779) GPR25 as a novel target to boost anti-tumor TRM responses
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(780) Investigating the role of Candida albicans gastrointestinal colonization on immune checkpoint therapy
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(780) Redox Index and Capacity Analysis (RICA) sheds light on NAD biology in tumor-infiltrating lymphocytes
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(780) SUSD2 mediates the transition of CD8+ T-cells towards terminal exhaustion in the tumor microenvironment
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(781) Anti-tumor activity of CTLA4-blockade-sensitive and insensitive CD8 T cells recognising the same low affinity neoepitope (IC50 for Kd 11,987 nM)
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(781) Fn14 Signaling in Glioblastoma-Associated Myeloid Cells Inhibits Th1-Driven Anti-Tumor Immunity
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(781) The CD83 axis between Tregs and CCR7+ dendritic cells governs anti-tumor immune responses
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(782) Identifying the Mechanism of CAR T Cell Metabolic Improvements Associated with Compound 991 Treatment
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(782) Natural Antibody Recognition of DAMPs Is Required for Inflammasome-Driven Anti-Tumor Immunity
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(782) Stimulating the resolution of inflammation overcomes CD8+ T cell exhaustion and boosts immunotherapy
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(783) CD1d Modulation Influences Tumor Immune Crosstalk in Triple-Negative Breast Cancer (TNBC) through NKT and Macrophage Interaction
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(783) Globotriaosylceramide (Gb3)-expressing B cells license anti-tumor T cell immunity
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(783) Microbial Metabolite D-Lactate Enhances CD4⁺ T Cell Effector Function by Rewiring Metabolism Independently of Its Catabolism
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(784) 3) Immunotherapeutic control of MHC I-heterogeneous tumors to minimize therapy resistance
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(784) Succinate Fuels CCR4⁺ Treg Expansion and Immune Escape in Aging Ovarian Tumors
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(784) Systemic Proteomic Remodeling Following Nephrectomy in Renal Cell Carcinoma
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(785) Activity in vivo of in vitro expanded and adoptively transferred antigen-specific CD8+ T cells against neoepitopes that mediate tumor rejection
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(785) Functional heterogeneity of γδ T cells in anti-tumor immunity
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(785) Tumor extracellular vesicles induce immunosuppressive myeloid cells via TIGIT/CD155 axis, dampening NLRP3-driven inflammatory response in glioblastoma
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(786) Altered Lipid Antigens Drive Hidden Immune Activation in Aging Blood
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(786) Human γδ T Cell Anti-tumor Immune Responses
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(786) Ori-TTV particles enable potent in vivo CAR-T cell engineering for the treatment of hematologic malignancies and autoimmune diseases.
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(787) Adapting the sequential infection mouse model to improve the translation of preclinical cancer research and immunotherapy
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(787) Intratumoral administration of Sequential Heterologous Vaccine followed by intratumoral IL-15 complexes induces complete anti-tumor responses.
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(787) T Follicular Helper cell and CD8⁺ T Cell Dynamics in Breast Cancer: Insights from Patient Samples and Immune Checkpoint Blockade in Murine Model
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(788) Experimental Type 1 Diabetes in Tumor Host Generates Metabolically Superior CD8+IGF1R+IGF1+ T Cells for Improved Control of Tumor Growth
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(788) Overcoming age-related tumor progression using the HEPLISAV-B vaccine in combination with immunotherapies
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(788) RNF43 p.G659fs activates the PI3K/AKT-HLA-E axis to drive NK cell dysfunction in MSI-high colorectal cancer
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(789) A novel microbial-derived metabolite counteracts exhaustion programming in CD8 T cells
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(789) Interrogating mechanisms of a novel anti-tumor CD4 response
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(789) Role of ADAR1 in regulating IFN and TNF mediated responses
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(790) Peripheral memory T cells with self-renewing properties increase with tumor-targeting IL-12 immunocytokine therapy
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(791) Between Nodes and Niches: Tracing Tumor-Associated B Cell Trafficking and Effector Maturation in NSCLC
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(791) NKG7 is upregulated by IL-2/T-bet pathway during effector differentiation of cytotoxic CD8+ T cells
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(791) SUMOylation regulates CD8 T-cell metabolic exhaustion in the lymphoma tumor microenvironment
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(792) Tissue-Resident Cytotoxic γδT Cells in Anti-tumor Immunity
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(792) Uncovering the dynamic interplay between immune surveillance and mutational landscape during tumor initiation
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(793) CD4-Targeted CAR-Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia
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(793) Establishment of patient-derived lung epithelial progenitor lines as a foundation for autologous immune and tumor modeling
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(794) High-resolution spatial mapping of cell state and lineage dynamics in the tumor microenvironment with PEtracer
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(795) CNPY2 controls Macrophage Metabolic Programming and Epigenetic Remodeling
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(795) Potentiating Natural Killer Cell-mediated Cytotoxicity in Medulloblastoma
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(796) Endogenous neoantigen specific antibodies mediate anti-tumor responses and determine vaccine efficacy
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(796) The Effects of Granulocyte Macrophage Stimulating Factor on Cancer Cell Viability in vitro and in vivo
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(797) MCT4 loss reprograms MC38 tumor environment and potentiates mRNA cancer-vaccine therapy
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(797) Phospholipase PLA2G2D Suppresses Adaptive and Innate Immune Cells to Dampen Anti-Tumor Immunity
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(798) Adenosine Suppresses Microglial Immunity in Breast Cancer Brain Metastasis
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(798) Oncogenic mutations drive immunity through a neuron-ILC axis
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(799) Nanobody-STING Agonist Reprogram the Tumor Microenvironment and Improve Adoptive Cell Therapy for Solid Tumors
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(799) Spatial Profiling Links Metabolic Reprogramming and Stromal Fibroblasts to PD-L1-Discordant NSCLC Responses
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(800) Increasing the Efficacy of Chemotherapy by Rescuing the Innate Immune Response
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(800) The HFE H63D Polymorphism Alters Anti-Tumor Immunity in Pancreatic Cancer
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(801) USP22 orchestrates an NK-suppressive program for tumor immune evasion
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(802) Development of an ultra-high-plex immunofluorescence assay to investigate the tumor-immune microenvironment on the CellScape platform with EpicIF
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(802) Multiplex Made Practical: An Educational Workflow Using Directly Conjugated Primary Antibodies
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(803) LRP1-Targeted Polymeric Nanoconjugates for BBB Penetration and Time-Specific Delivery of PD-L1–Blocking Peptides in Melanoma Brain Metastases
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(803) MR1-driven activation of MAIT cells orchestrates anti-tumor immunity in melanoma
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(804) Estrogen signaling through estrogen receptor beta in Tregs regulates the differential response to therapy in head and neck squamous cell carcinoma
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(804) Selective Effects of Fenbendazole on Normal Human Dermal Fibroblasts
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(805) Tissue specific cues govern melanoma specific resident memory CD8⁺ T cell persistence in skin and tumor draining lymph nodes
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(806) Safety, tumor targeting and efficacy profile of a lyophilized bioengineered strain of S. typhimurium (iSTORM-0L) in PDAC treatment
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(806) The Autoimmune-Associated PTPN22 Variant Promotes Anti-Tumor Immunity in Melanoma
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(807) Phosphatidylserine on Hypoxic Tumor-Derived sEVs Regulates ADAM17 Activity and T-Cell Fate
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(808) Interleukin 15 stimulation augments myeloid-derived suppressor cell immunosuppression in cross-species models of sarcoma
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(808) Stk11 loss in lung adenocarcinoma increases tumor CXCL16 and is associated with an expansion of Areg+ CXCR6+ IL-17-producing gamma delta T cells
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(809) IL-33 suppresses tumor growth through attenuating Treg-derived chemokines and MDSC recruitment
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(810) STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity
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(811) Soluble TREM2 Promotes Triple-Negative Breast Cancer Advancement via the TG2-AKT Axis
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(812) Meta-Data Informed Microphysiological System Replicates in vivo Macrophage Regulation of CD8+ T Cell Migration in Renal Cell Carcinoma
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(813) Treatment Responses Alter Myeloid Activation in BRAF-Mutant Melanoma
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(814) The Dichotomy of Tumor Control by Recruited and Resident Tumor-Associated Macrophages
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(816) Post-operative IL-15 enhances the immunosuppressive effects of myeloid derived suppressor cells in sarcoma
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(817) Imipridone treatment activates canonical NFkB and inflammatory signaling in THP1 differentiated macrophages
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(818) Distinct effects of different programmed cell death modalities on immune microenvironment of major molecular subtypes of breast cancer
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(819) Reprogramming of Glioblastoma-Immune Crosstalk to Overcome Immunotherapy Failure
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(820) The Invisible Influence: Microbial Dynamics Impacting Tumor Immunity in NSCLC
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(821) eEF2K Drives Immune Evasion in Melanoma through Cyclin D1–Dependent Stabilization of PD-L1
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(822) A Novel Balloon Procedure for Generating Physiologically and Clinically Relevant Orthotopic Colorectal Cancer Mouse Model
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(823) Spatial and vascular determinants of tumor-infiltrating lymphocyte expansion in glioblastoma
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(824) In Vitro Characterization of Glioblastoma Inflammatory Signatures: Insights into Resistance and Model Selection
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(825) Inflammasome Activation Limits Radiotherapy-Induced Antitumor Immunity and Shapes CD8⁺ Responses in a Sex-Dependent Manner
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(826) ACKR1⁺ Venular Endothelial Cells Orchestrate T Cell Infiltration and Angiogenesis in Solid Tumors
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(827) Targeting Myeloid-Derived Suppressor Cell-Mediated Immunotherapy Resistance in Pediatric Brain Cancer
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(828) The Role of gC1qR and C1q in Tumor Cell Hijacking of Mitochondria from T Cells
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(829) Interleukin-9 Receptor Signaling Promotes an Immunosuppressive Tumor Immune Microenvironment in Oncogene-Driven Non-Small Cell Lung Cancer
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(830) Functional Analysis of GAPDHP65 Suggests a Role in Triple-Negative Breast Cancer Viability
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(831) Molecular Insights into the RELT–FLNA Interaction and its Role in Breast Cancer Cells
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(832) Live but Stressed/damaged Tumor Cells Directly Stimulate Naïve CD8+ T cells
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(833) Tumor Egfl6 is a new driver of neutrophil extracellular traps (NETs) in ovarian cancer
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