Immune Mechanisms of Human Disease (HUM)

Animal Models and Multi-omics Technology

Late-breaking: Immune Mechanisms of Human Disease

Metabolism, Innate Immunity, and Responses to Infection

Orchestration of the Adaptive Immune Response

Primary Immune Deficiency and Immune Dysregulation

Tissue and Mucosal Immunity

(183) A 61-Parameter CyTOF Panel for Comprehensive Profiling of Human PBMC to Characterize Activation, Differentiation, Checkpoints and Cytokines

(184) Colonic immunometabolic host response mechanisms to ionizing radiation in a mouse model of acute radiation syndrome

(185) PBMCs from people with HIV imprint diet-sensitive hepatic inflammation and lipid remodeling in NSG mice

(186) Comparative Intravital Imaging of C-kit Expression and Its Co-localization with a C-kit–Targeting Antibody in Balb/c and Humanized hIgE/hFcεRI Mice

(187) Mouse Models Drive Progress in Alport Syndrome Therapy Development

(189) Changes in lumbar spinal cord Alox12 in doxycycline inducible HIV Tat transgenic mice, a model of HIV neuropathy

(190) C5 Inhibitor Nomacopan Preserves Mitochondrial Integrity and Function in Combined Traumatic Brain Injury and Hemorrhagic Shock

(191) Gene expression profiling of immune cells in blood from patients with coronary Artery Disease

(193) Changes in genes in the TLR signaling pathway within the lumbar spinal cord of doxycycline-inducible Tat transgenic mice following Tat induction

(194) Intravital imaging comparison of C-kit expression and co-localization with C-kit–targeting antibody in Balb/C and humanized hIgE/hFcεRI mice

(195) Spatial immunoprofiling of human colon in health and disease: insights into inflammation

(196) Characterizing the role of ovarian hormones in regulating sex differences in baseline immune parameters

(197) Multi-omic Signatures of Vaccine Responses in Healthy Early Adolescents

(200) Uncovering T cell antigens in sarcoidosis

(201) Novel chemokine-peptide-MHC II CAR-T cell treatment alleviates inflammation in chronic beryllium disease

(202) High-Dose Influenza Vaccination Partially Restores Impaired T Follicular Helper Cell Function in Aging and HIV

(204) Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus

(204) Identification of antigen-experienced human anti-HER2-specific B cells from peripheral blood

(205) Discovery and validation of novel IgA proteases for the treatment of autoimmune and inflammatory diseases

(205) T-bet high atypical memory B cells exhibit effector memory features in mRNA vaccine recipients

(206) Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency contributes to Treg Dysfunction and Susceptibility to Systemic Lupus Erythematosus

(206) Short PDE4D isoforms potentiate pathologic Th17 function and mark arthritis-adapted memory CD4 T cells

(208) Cannabidiol Attenuates UVB-Induced Skin Inflammation via STAT3/c-Jun Suppression and Silicone Polymer–Based Topical Delivery

(208) Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident T follicular helper cells in humans

(209) Antibody Signatures of Illness Trajectories: Comparative FLow-based Immune Profiling (FLIP) in Long COVID

(209) IL-17C–activated MAIT cells drive fibrosis in immune-mediated liver disease

(210) Characterization of the circulating T-cell landscape in cutaneous lichen planus patients

(210) DOCK 8 with large vessels Vasculitis

(211) Investigating the Regulation of T Cell Activation by Microplastics and Selected Perfluoroalkyl Substances via High-Dimensional Spectral Flow Cytometry

(211) Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo

(212) Lymphocytic Variant Hypereosinophilic Syndrome is Composed of pathogenic CD4+ T cells with Features Distinct from those in T Cell Lymphoma

(212) The Immunological Landscape of Biliary Atresia: Focus on Th2 and Th17 Profiles

(213) Sex Differences in Hematological and Immunological Features of Sarcoidosis

(214) Age-Linked Neutrophilic Inflammation Signatures Associate with Disease Severity in Primary Ciliary Dyskinesia

(214) T cell O-GlcNAcylation increases in patients with allergic rhinitis after the natural pollen season

(215) Neutrophil Activation Signature Associated with Pulmonary Fibrosis in Hermansky–Pudlak Syndrome Type 1

(216) Multi-omics and longitudinal immune profiling uncover a distinct monocyte phenotype distribution and function in Kawasaki disease

(217) Effects of biological therapy with anti-TNF and anti-IL-12/IL-23 antibodies on parodontitis in patients with inflammatory bowel diseases

(218) Dual RNA-Seq Reveals ESX-1/ESX-5–Mediated Virulence and Host-Specific Transcriptomic Responses to Mycobacterium marinum Infection

(218) Prevalence of IL12B rs3212227 Polymorphism in Patients With Plaque Psoriasis From Guatemala

(219) Dipyridamole as a Potential NEK7–NLRP3 Inflammasome Modulator in Adult Onset Still’s Disease and Pre Myelodysplastic Syndrome

(219) Immunometabolic Dichotomy Underlying Monocyte-Driven Kawasaki Disease and Lymphocyte-Driven MIS-C Pathogenesis

(220) 17b-Estradiol Potentiates the Type I Interferon Signature and Pro-inflammatory Cytokine Profile in SLE via ERa Signaling

(220) T cell dysregulation in pediatric obesity

(221) PROTAC-Mediated SHP2 and STAT3 Degradation as a Therapeutic Strategy for Rheumatoid Arthritis

(221) Unraveling the Immunopathology of Infection-Associated Chronic Illnesses: Sex Differences and Predictive Diagnostics

(222) Characterizing the Roles of Dysferlin Deficiency in Function, Polarization, and Secretome of Human iPSC-Derived Macrophages

(222) CMKLR1 as a potential target of cardiometabolic disease in PLWH

(223) Increased expression of Response Gene to Complement-32 in PBMC and kidneys of patients with lupus nephritis.

(223) Post-COVID impairment of memory T cell responses to community-acquired pathogens is associated with underlying metabolic dysfunction

(224) Heightened Krüppel-like-factor-6 alters Treg lipid metabolism in autoimmune hepatitis

(224) Interferon lambda 4 genotype determines baseline expression of interferon-stimulated genes and lipid metabolism-related genes in the healthy liver

(225) eQTL analysis of SLE B cells reveals functional genomic regulatory variation associated with autoimmunity

(225) Investigating features of dengue immunity that drive enhancement versus protection

(226) Comprehensive Biomarker Strategy to Monitor GNTI-122, an Engineered Regulatory T Cell Therapy in Clinical Development to Treat Type 1 Diabetes

(226) Longitudinal T cell receptor repertoire sequencing identifies specific T cell clones with rare CDR3 residues against malaria

(227) Plasma lipidomics in North Indian children with acute Kawasaki disease

(227) Short-term rapamycin treatment of an older human cohort alters immune and inflammatory markers but fails to re-set the epigenetic biological clock

(228) Dysregulated Myelopoiesis and Altered Neutrophil Metabolism in Obese Adults: A Role for Glutaminase in Hypoxia-Induced Cell Survival

(229) Age and Activity-Dependent Differences in Intraocular Immune Profile of Chronic Autoimmune Uveitis

(229) Cellular Predictors of Chronicity in Lyme Arthritis

(230) Flow Cytometric Antigen-Specific Immune Responses in Latent Tuberculosis Infection: A Comparison Between Low- and High-Endemic TB Settings

(230) Investigating the CXCR4/CXCL12 Axis to Predict Multiple Sclerosis Symptom Onset

(231) Microvascular Alterations in Infection-Associated Chronic Illnesses: Insights from Nailfold Capillaroscopy and NASA Lean Testing

(231) Subclinical disease detection and immune profiling in siblings of patients with Enthesitis-related arthritis category of juvenile idiopathic arthritis

(232) Mast Cell and TGF-β interactions in a model of Metabolic Dysfunction-Associated Steatotic Liver Disease and responses to cannabinoid intervention.

(232) Racial Disparity in Immune Response: Prospective Study in Obesity-Associated Lupus Patients

(233) Linking multi-barrier permeability with cognitive dysfunction in Borrelia infection-associated chronic illness

(233) Modeling Inflammation, Neutropenia, Bone Marrow Failure, and Lymphoproliferation caused by TLR8 (INFLTR8) in B6 Mice

(234) Metabolic Injury Niche Suppresses Macrophage Efferocytosis and Delays Recovery in Acute Kidney Injury

(235) A causal link between autoantibodies and neurological symptoms in long COVID

(235) Longitudinal Blood Single-Cell Profiling Reveals Divergent Immune Trajectories and Non-Response Programs in Inflammatory Bowel disease Therapies

(236) Bronchiectasis in Myasthenia Gravis: A Clinically Relevant Comorbidity Defining a High-Risk Triad with Thymoma

(236) Evidence of Persistent Thromboinflammation and Complement Consumption in Patients with Long COVID

(237) Antibodies cloned from a patient with Idiopathic CD4 Lymphopenia induce potent anti-T and B cell complement-dependent lysis

(237) The role of mevalonate pathway metabolites in immune homeostasis

(238) Altered lipid metabolite profiles in neurocognitive impairment in long COVID

(239) Multisystem Inflammation with Elevated IgG4: Recognizing and Early Diagnosing IgG4 Related Disease

(240) Immunomodulatory effects of non-psychoactive cannabinoids in a model of metabolic dysfunction-associated steatotic liver disease (MASLD)

(241) PD-1/PD-L1 enrichment in the IPF lung as a mechanism of senescent cell immune evasion.

(242) IFNγ-Driven Th17 and Neutrophil Responses Promote Rapid Polycystic Kidney Disease Progression

(243) Spatially resolved gene programs and cell neighborhoods of scleroderma fibroblasts

(244) T Cells at the Maternal–Fetal Interface: Placental Dynamics in Healthy and Complicated Pregnancy

(245) Single-cell RNA sequencing reveals conserved T cell populations across kidney tissue and urine of patients with immune checkpoint inhibitor nephritis

(246) Unbiased Transcriptomic Clustering Reveals an Inflammatory PEC Niche Associated with Cytokine and RAAS Signaling in Glomerular Disease

(247) Human Apolipoprotein B Specific CD8 T Cells in Atherosclerosis

(248) Single-Cell Analysis Reclassifies Eczematous Mycosis Fungoides as Severe Atopic Dermatitis

(249) Aberrant NK Cell Migration and Differentiation Underlie Immune Dysregulation in Endometriosis

(250) Interferon Regulatory Factor 5 modulates CD11b⁺ cell composition and NLRP3-related factors in emphysema pathogenesis

(251) Non-Invasive Theranostics for Endometriosis

(252) Upregulation of autophagy related genes in the dorsal root ganglion in CD137L KO mice, link to peripheral nerve injury induced-peripheral neuropathy

(253) Keratinocyte VISTA suppresses skin IFN-I and inflammatory crosstalk after UV exposure

(254) Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension

(255) Tissue-resident, circulating and plaque-homing CD4+ T cells in human atherosclerosis

(256) Longitudinal autoantibody profiling in systemic sclerosis uncovers biomarkers associated with disease progression

(257) Functional Identification and Characterization of Human Tissue Resident Memory T Cells Using Ex Vivo Lung Perfusion

(258) Longitudinal Immune Responses to Radiotherapy Differentiate Progression-Free Survival Outcomes in Esophageal Cancer

(259) Spatial–glycomic immune signatures in metabolic dysfunction-associated steatotic liver disease (MASLD) progression

(261) A Co-expression Network Identifies a Dominant Immune-Activation Module Predicting Severity in Nasal Polyps