Computational and Systems Immunology (COMP)

Computational and Systems Immunology I

Computational and Systems Immunology II

(131) Reconstructing Immune Time from a Single Snapshot: The Single-Cell Brownian Bridge Framework for Reverse-Time Evolutionary Inference

(132) Robust T Cell Activation Kills Tumors Regardless of T Cell Specificity

(133) Pilot study of gestational PFAS exposure on child blood transcriptional profiles

(134) Th10 and activated Tfh1 expansion correlate with strong, while Tfr expansion correlate with poor responses to Fluzone High Dose in older adults

(135) Modeling Multiple Interconnected TLR Signaling Cascades is Needed to Recapitulate the Anti-Tumor Activity of Bone Marrow-Derived Macrophages

(136) Mathematical Modeling of Vertebrate Memory-Based Immunity and Autoimmunity: A Computational Study of Memory Dynamics and Innate-Adaptive Feedback

(137) Spatial Transcriptomics Reveals Immune Remodeling in Recurrent Oligodendroglioma

(138) Single-cell RNA and CITE-seq analysis of human CD4⁺ T cells reveals age-associated upregulation of IL-32

(139) TCR germline diversity reveals evidence of natural selection on variable and joining alpha chain genes

(140) Classical and Transformer-based Machine Learning Approaches for Modeling T Cell Receptor Specificity for Cancer Neoepitopes

(140) MRGPRX2 Activation Triggers a Distinct Transcriptional Response That is Enriched in Chronic Spontaneous Urticaria and Atopic Dermatitis Lesions

(141) Building Clustering Consensus and Exploring the Immune Landscape in Mouse Spleen in Single-Cell Resolution

(141) Systems immunology approach to mapping malaria disease trajectory identifies conserved gene modules associated with severity.

(142) Integrative Multi-omics Reveals Myeloid Signatures of Neoadjuvant Chemotherapy Response in Pancreatic Ductal Adenocarcinoma (PDAC)

(143) Cluster-free annotation and cell state classification using Bayesian networks and Wasserstein's Distance

(143) Inside the wavering mind of an NK cell: Mathematical Modeling of NK cell Activation

(144) B Cells Break the Structure Rule: Recognition of Intrinsically Disordered Epitopes in the SARS-CoV-2 Spike Model

(144) Non-linear Generalizable Machine Learning Re-Analysis of Plasma Proteomics and Single-Cell Immune Network for Classification of COVID-19 Severity

(145) Gestational diabetes fetal programming activates the PI3K-Akt and NETosis inflammatory axis in neonatal endothelial colony-forming cells

(145) Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming

(146) Blood multi-omic profiling reveals systemic immune programs and tractable biomarkers underlying checkpoint inhibitor–induced toxicities

(146) PD-1 regulates CD8+ T cell tissue resident memory differentiation and function following influenza infection

(147) A Single-Cell Atlas of TCR Clonality and T Cell States in Blood Across Health and Disease

(147) MTHFR Allele and One-Carbon Metabolic Profile Predict Severity of COVID-19 Disease

(148) Advanced Machine Learning Across Multiple Vaccines to Predict Durable Immunogenicity using the Immune Signatures Data Resource

(148) XTEP: A Structure-Informed Algorithm to Predict T Cell Cross-Reactivity

(149) High risk blood myeloid dysregulation is elevated in obesity and is reduced by lifestyle interventions

(149) YY1 regulates B cell lineage plasticity via transcriptional, miRNA post-transcriptional, and epigenetic mechanisms

(150) ImmgenT Regulatory T Cell Atlas.

(150) Integrative Curation of Human and Rhesus Macaque Immunoglobulin Germline Loci for Population-Scale Immunogenomics

(151) Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic Targets

(151) ImmunoFoundation: A Multimodal Deep Learning Approach to Immunogenicity Prediction

(152) A single-nucleus atlas of skeletal muscle regeneration identifies distinct macrophage populations and their cytokine environments.

(152) ViSENet: Joint Sequence and Structure Embeddings of Spike Proteins for Predicting Viral Dynamics

(153) CMV-specific clonal expansion of Th1, GZMK⁺ CD8⁺, and TEMRA T cells revealed by human PBMC profiling

(153) Single-Cell Multi-Omics Reveals T Cell Dysregulation in Sarcoidosis

(154) Activation of cDC2 and monoDCs on Day 1 is Associated with Stronger Responses to the Fluzone High-Dose in older adults.

(154) Unsupervised clustering identifies a CD161⁺ MAIT-like T cell population associated with anti–PD-1 response and immune-related toxicity in melanoma

(155) GIBLE: Inferring time-resolved B cell lineage trees from spatial BCR sequencing

(155) Longitudinal single-cell atlas to identify B cell subpopulations and states associated with human vaccine responses

(156) Common and divergent dynamic changes of the human plasma metabolome across the first week of life in the Gambia & Papua New Guinea

(156) Single-nuclei multiome-seq and modeling of intestinal cell types nominates regulatory mechanisms driving IBD genetic risk and anti-TNF nonresponse

(157) Large-scale Network Analysis of the T cell Beta Chains in the AIRR Knowledge Commons

(158) A phenotypic switch confers resistance to CAR T cell immunotherapy in neuroblastoma

(158) Open resources and data from the Allen Institute: exploring immune health, rheumatoid arthritis, tissue immunity, and cytokine perturbations

(159) Cross-disease single-cell surface protein atlas reveals shared and disease-specific immune phenotypes across 2,000 donors and 40+ immune conditions

(159) The Immune Epitope Database: Revised Receptor Data and Integration with the Adaptive Immune Receptor Repertoire Knowledge Commons

(160) AZD5582-reactivated cells likely differ from productively infected cells

(160) Novel FlowSOM Meta-clustering Method leveraging Insights from Cell Biology

(161) ImmuneSpace in 2026: A Centralized Repository for Curated Human Immune-Profiling Data

(161) Mapping T cell phenotype with machine learning to optimize cancer immunotherapy

(163) A User-Friendly, Modality-Agnostic, Scalable Pipeline for High-Dimensional Immune Data Across Cytometry and Imaging Platforms

(164) An AI Framework to Reveal Disease-Driving CD4 T Cell Synapses in Sarcoidosis

(165) Comprehensive T-cell receptor repertoire analyses of HIV vaccine-induced T-cell response

(166) High Resolution Single-Cell Epigenetic Atlas of Immune Cell Types Reveals Gene Regulatory Circuits in Healthy Humans

(167) A biologically informed antibody language model framework to simulate somatic hypermutation and guide native-like antibody design

(168) A Method to Detect Differences in Heterogeneous Cell Populations Without Assuming a Specific Data Distribution leveraging SOM-based clustering

(169) Adaptive Immune Receptor Repertoire Knowledge Commons: data harmonization

(170) Deep functional interpretation of influenza-induced ciliary gene dysregulation through stepwise Large Language Model profiling

(171) An integrated cell atlas of the innate lymphoid cells in health and disease

(172) Enabling scalable adaptive immune receptor repertoire analysis with nf-core/airrflow

(173) Mechanistic models coupled with sequencing data for the prediction of variant/cell type-specific IL-10 responses

(174) Comparison of Bulk and Single-Cell B-Cell Receptor Sequencing Reveals Methodological Biases in Repertoire Analysis

(175) In silico Analysis of the Anti-Pruritic Immunomodulatory Mechanisms of Chunwangbosim-dan Components Using Network Pharmacology and Molecular Docking

(176) Mapping immune landscapes and immunopathomechanisms of inflammatory skin diseases through single-cell multi-omic analysis

(177) Representation Learning on Population-Scale Proteomics to Stratify Immune Checkpoint Inhibitor Outcomes

(178) Dysregulated host responses are associated with severe influenza A virus disease in individuals with arterial hypertension.

(179) Galectin 3 Expression in Gastrointestinal Tumors Identified Through Comprehensive Bioinformatic Mapping

(180) Multi-omic analysis of long COVID patients reveals obesity-associated metabolic dysfunction and inflammation in adipose-residing immune cells.

(181) Multi-omic Signatures of Baseline Immunity Shape Antiviral Responses in Adults and Infants

Late-breaking: Computational and Systems Immunology