Postdoctoral Fellow Harvard Medical School Cambridge, Massachusetts, United States
Disclosure(s):
Samuel C. Markson, PhD: No financial relationships to disclose
Introduction/Rationale: In addition to its established role in T cell exhaustion, PD-1 is also upregulated in CD8⁺ tissue-resident memory (TRM) cells.
Methods: Here, we examine the cell-intrinsic contributions of PD-1 to CD8⁺ TRM cell generation and function during influenza infection by comparing wild-type (WT) and PD-1 knockout (KO) antigen-specific CD8⁺ T cells.
Results: Transcriptional and epigenetic profiling of these populations reveals early and persistent changes in transcriptional regulation and fate decisions.
Conclusion: Our findings provide new insight into how PD-1 signaling influences the differentiation and function of CD8⁺ T cells.
