Impact of a Modernized Immunology CURE on Undergraduate Student Learning and Scientific Literacy

Introduction/Rationale: Course-Based Undergraduate Research Experiences (CUREs) are effective tools that give students unique insights into the scientific process and opportunities to build creativity, analytical, and technical skills. CUREs also boost student retention in STEM fields and build stronger scientific literacy and communication skills. A successful CURE depends on many factors such as research topic, instructor, and even classroom dynamic, however access to modern equipment and facilities severely limits potential projects in the undergraduate setting.
Designing an Immunology CURE is inherently difficult and complex due to reliance on sensitive equipment, expensive reagents, and limitations to facilities. This CURE was developed with those concerns in mind, all while giving students exposure to cell culture methods and assays utilizing the established THP-1 monocyte cell line. Additionally, the CURE was designed to encourage students to explore their own ideas and research questions with the hypothesis that doing so would significantly improve learning outcomes, science literacy and science communication.

Methods: On week 1, students toured our facilities and reviewed scientific literature through an assignment and guided discussion. Over the course of 13 weeks, students learned fundamental methods such as ELISA, immunofluorescence, apoptosis and phagocytosis assays via flow cytometry, and viability assays. Students presented their research findings at our annual research symposium.

Results: Feedback showed students responded well to the CURE, with most reporting stronger motivation and attachment to their project than in other science courses. Sentiment on belonging and confidence presenting a poster were also significantly higher.

Conclusion: This CURE was designed to give students a pertinent and modern Immunology research experience. Although many challenges still exist, the benefits were shown to be powerful and, in some cases, life-changing for the students.