Targeting B Cells and Innate Immune Functions in Autoimmunity

Moderator(s)

• 

  John Mountz, PhD MD

  Professor of Medicine
  Univ. of Alabama, Birmingham
  BIRMINGHAM, Alabama, United States

Presentations:

• 8:00 AM - 8:15 AM US ET

  Metabolic checkpoint AhR prevents pathogenic B cell expansion in murine lupus
  

  Author: John D. Mountz, PhD MD – Univ. of Alabama, Birmingham
• 8:15 AM - 8:30 AM US ET

  SP2H selectively depletes Stimulator of Interferon Genes (STING), reducing inflammation and improving survival in Trex1-/- mice
  

  Author: Richard Bethell, DPhil (he/him/his) – Sulis Therapeutics
• 8:30 AM - 8:45 AM US ET

  Reduced BCMA Signaling Disrupts the BAFF/APRIL Axis and Promotes Inflammatory Cytokine Production by B Cells in Multiple Sclerosis.
  

  Author: Gaurav Kumar, PhD (he/him/his) – Oklahoma Med. Res. Fndn.
• 8:45 AM - 9:00 AM US ET

  The antigen-specific immunotherapy, AKS-107, selectively depletes anti-insulin B lymphocytes in the pancreas and reduces insulitis in T1D-prone mice
  

  Author: Tyler W. Jenkins, PhD – Vanderbilt Univ. Med. Ctr.
• 9:00 AM - 9:15 AM US ET

  Functional dichotomy of GC-Derived Memory B Cells in Lupus: A Role for FCRL5+ MBCs in ASC Differentiation
  

  Author: Ajitanuj Rattan, PhD (he/him/his) – Boston Children's Hosp., Harvard Med. Sch.
• 9:15 AM - 9:30 AM US ET

  A Six-month Ketogenic Diet Alters The Immune And Metabolic Landscape In Multiple Sclerosis
  

  Author: Wesley Godfrey – Johns Hopkins Univ. Sch. of Med.