Full Schedule

7:00 AM - 8:00 AM US ET

CAREER/NET19 - A Deeper Dive with Frances Lund (registration required)

Location: 101

Career/Networking (CAREER/NET)

7:00 AM - 8:30 AM US ET

AAI Education Committee Meeting (invitation only)

Location: 154

8:00 AM - 9:00 AM US ET

LYM10 - AAI ASPIRE Awards Symposium

Location: 102

Chair: – Cornell Univ.

Award Recipient: – Yale Univ.

Award Recipient: – Mem. Sloan Kettering Cancer Ctr.

8:00 AM - 9:00 AM US ET

LYM10 - Determinants and augmentation of effective anti-tumor immunity in kidney cancer

Location: 102

Speaker: – Yale Univ.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

8:00 AM - 9:00 AM US ET

LYM10 - Insights into VEXAS syndrome: How the cell death machinery unleashes inflammation

Location: 102

Speaker: – Mem. Sloan Kettering Cancer Ctr.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

8:00 AM - 9:30 AM US ET

TIME5 - Tumor and Immune Cell Crosstalk

Location: 156

Moderator: – University of Kansas Medical Center

Moderator: – Yong Loo Lin School of Medicine, NUS

8:00 AM - 9:30 AM US ET

EDU3 - Conversations that Connect: Helping the Public Understand, Trust, and Engage with Science, Sponsored by the AAI Public Communications Comm.

Location: 151

Chair: – Univ. of Colorado Anschutz

*Panelist: – Unbiased Science

*Panelist: – The Evidence Collective

*Panelist: – A2 Biotherapeutics

8:00 AM - 9:30 AM US ET

NEUR2 - Neurodegenerative & Autoimmune Disorders

Location: 157

Moderator: – Harvard Med. Sch.

Moderator: – Temple Univ. Katz Sch. of Med.

8:00 AM - 8:15 AM US ET

Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells

Location: 157

Author: – Brigham and Women’s Hosp, Harvard Med. Sch.

Neuroimmunology (NEUR)

8:15 AM - 8:30 AM US ET

Aging-Associated Nrf2 Loss in Microglia Exacerbates Neuroinflammation and Trained Immunity

Location: 157

Author: – Indiana University School of Medicine

Neuroimmunology (NEUR)

8:30 AM - 8:45 AM US ET

CD40+ MHC-II+ astrocytes promote Th17 cell-driven CNS autoimmunity

Location: 157

Author: – Harvard Medical School

Neuroimmunology (NEUR)

8:45 AM - 9:00 AM US ET

Gamma-Delta T cell–microglia crosstalk drives CD8⁺ T cell infiltration and promotes Alzheimer’s-like pathology in APP/PS1 mice

Location: 157

Author: – Harvard Med. Sch.

Neuroimmunology (NEUR)

9:00 AM - 9:15 AM US ET

Repeated brain resident memory T cell reactivation induces microglial and T cell remodeling and sustained microglia activation in Alzheimer’s disease

Location: 157

Author: – Dartmouth College

Neuroimmunology (NEUR)

9:15 AM - 9:30 AM US ET

Meningeal lymphoid hubs support autoreactive immune responses

Location: 157

Author: – National Institutes of Health

Neuroimmunology (NEUR)

8:00 AM - 9:30 AM US ET

HUM2 - Surprising Insights on Human Immunology from the Study of Monogenic Inborn Errors of Immunity, Sponsored by the Clin. Immunol. Soc. (CIS)

Chair: – Uniformed Services Univ.

Chair: – Columbia Univ.

Speaker: – Vanderbilt Univ. Med. Ctr.

Speaker: – New York Univ. Grossman Sch.l of Med.

Speaker: – Columbia Univ.

Speaker: – Uniformed Services Univ.

8:05 AM - 8:25 AM US ET

A novel inborn error of immunity perturbs linear ubiquitin homeostasis and causes pyoderma gangrenosum

Location: 104C

Speaker: – Vanderbilt Univ. Med. Ctr.

Human/translational immunology

8:25 AM - 8:45 AM US ET

VEXAS syndrome and somatic auto inflammatory diseases

Location: 104C

Speaker: – New York Univ. Grossman Sch.l of Med.

Human/translational immunology

8:45 AM - 9:05 AM US ET

Arrested development: understanding the basis of NK cell sensitivity to human helicase deficiencies

Location: 104C

Speaker: – Columbia Univ.

Human/translational immunology

9:05 AM - 9:25 AM US ET

CBM-opathies: New insights on lymphocyte metabolism and effector function

Location: 104C

Speaker: – Uniformed Services Univ.

Human/translational immunology

8:00 AM - 9:30 AM US ET

COMP5 - Systems-level Human Immune Profiling Data Resources and Analysis, Sponsored by the Human Immunol. Project Consortium (HIPC), La Jolla Inst. for Immunology

Location: 153C

Chair: – HIPC Coordinating Center

Chair: – Yale School of Medicine

8:00 AM - 9:30 AM US ET

HIPC Coordinating Center

Location: 153C

Speaker: – HIPC Coordinating Center

8:00 AM - 9:30 AM US ET

HIPC Coordinating Center

Location: 153C

Speaker: – Yale School of Medicine

8:00 AM - 9:30 AM US ET

Host Genetics and B Cell Reprogramming by Epstein–Barr Virus

Location: 153C

Speaker: – Yale University

8:00 AM - 9:30 AM US ET

Immune memory to infection and vaccination in human tissues

Location: 153C

Speaker: – Columbia University

8:00 AM - 9:30 AM US ET

Placental Immune Cell Dynamics in Healthy and Complicated Pregnancies: Insights from 1.2 Million Maternal and Fetal Cells

Location: 153C

Speaker: – Massachusetts General Hospital/Harvard Medical School

8:00 AM - 9:30 AM US ET

HUM3 - Tissue and Mucosal Immunity

Location: 104AB

Moderator: – Benaroya Research Institute

Moderator:

8:00 AM - 8:15 AM US ET

Male-Biased Macrophage Signaling and CD8 T Cell Dysfunction Drive Immunosuppression in Pulmonary Fibrosis

Location: 104AB

Author: – Univ. of California, Davis

Immune Mechanisms of Human Disease (HUM)

8:15 AM - 8:30 AM US ET

Modelling of early-life immunity shaped by contrasting environments

Location: 104AB

Author: – Karolinska Institute

Immune Mechanisms of Human Disease (HUM)

8:30 AM - 8:45 AM US ET

Myeloid STAT4 at the Intersection of Sleep Disruption and Hyperlipidemia: A Molecular Link Between Lifestyle Stress and Atherogenesis

Location: 104AB

Author: – Macon & Joan Brock Virginia Health Sciences at Old Dominion University

Immune Mechanisms of Human Disease (HUM)

8:45 AM - 9:00 AM US ET

Immunometabolic Defects in Intestinal CD8⁺ T Cells Disrupt Epithelial Integrity in treated people with HIV

Location: 104AB

Author: – Ragon Institute of MGH, MIT, and Harvard

Immune Mechanisms of Human Disease (HUM)

9:00 AM - 9:15 AM US ET

A Specific Subset of Low-Density Neutrophils Aggravates Endothelial Denudation via NET-Mediated ANXA1 Sequestration: Implications for Plaque Erosion

Location: 104AB

Author: – Tongji Hospital of Tongji University, Tongji University School of Medicine

Immune Mechanisms of Human Disease (HUM)

9:15 AM - 9:30 AM US ET

Olfr2 Regulates oxLDL Signaling and Processing, Driving a Pro-inflammatory Foamy Macrophage Phenotype

Location: 104AB

Author: – Augusta Univ.

Immune Mechanisms of Human Disease (HUM)

8:00 AM - 8:15 AM US ET

Deletion of RIAM in myeloid cells accelerates tumor growth by macrophage reprogramming

Location: 156

Author: – The University of Texas MD Anderson Cancer Center

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

8:15 AM - 8:30 AM US ET

Olfactory receptor 2+ tumor-associated macrophages activate CD8+ T cells to suppress tumor growth

Location: 156

Author: – Med. Col. of Georgia, Augusta Univ.

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

8:30 AM - 8:45 AM US ET

MARCKS Drives Immunosuppressive Signaling in Tumor-Associated Macrophages to Promote Lung Cancer Progression

Location: 156

Author: – Univ. of California, Davis

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

8:45 AM - 9:00 AM US ET

Respiratory viral infections prime accelerated lung cancer growth

Location: 156

Author: – University of Virginia

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

9:00 AM - 9:15 AM US ET

GARP+ Erythroid Regulatory Cells (G-ERCs) define spatially organized immunosuppressive niches that restrain anti-tumor immunity

Location: 156

Author: – Ohio State Univ.

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

8:00 AM - 11:15 AM US ET

NEUR1 - Major Symposium E: Neuroimmune Landscapes Across the Body: Circuitry and Cytokines

Location: 253

Chair: – Univ. of Pittsburgh

Chair: – Icahn Sch. of Med. at Mount Sinai

Speaker: – Icahn Sch. of Med. at Mount Sinai

Speaker: – Weill Cornell Med. Sch.

Speaker: – Harvard Medical School

Speaker: – Univ. of Pittsburgh

Speaker: – GIMM

Speaker: – Massachusetts General Hosp.

Speaker: – Feinstein Inst. at Northwell

Neuroimmunology (NEUR)

8:00 AM - 8:33 AM US ET

Sensory interorgan neuroimmune circuits

Location: 253

Speaker: – Icahn Sch. of Med. at Mount Sinai

Neuroimmunology (NEUR)

8:33 AM - 9:06 AM US ET

Neuro-immune circuits regulate mucosal inflammation

Location: 253

Speaker: – Weill Cornell Med. Sch.

Neuroimmunology (NEUR)

9:06 AM - 9:21 AM US ET

The enteric nervous system shields colon cancer from immunosurveillance

Location: 253

Author: – Harvard Medical School

Neuroimmunology (NEUR)

9:21 AM - 9:54 AM US ET

Neuronal control of cutaneous inflammation

Location: 253

Speaker: – Univ. of Pittsburgh

Neuroimmunology (NEUR)

9:54 AM - 10:09 AM US ET

Tumor-innervating nociceptors drive immuno-suppressive monocyte differentiation to prevent T cell-mediated anti-cancer immunity

Location: 253

Author: – GIMM

Neuroimmunology (NEUR)

10:09 AM - 10:42 AM US ET

Neuroimmune circuits in allergy immunity

Location: 253

Speaker: – Massachusetts General Hosp.

Neuroimmunology (NEUR)

10:42 AM - 11:15 AM US ET

From the lab to FDA-approval: clinical translation of the inflammatory reflex

Location: 253

Speaker: – Feinstein Inst. at Northwell

Neuroimmunology (NEUR)

8:00 AM - 11:15 AM US ET

LYM9 - Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Location: Ballroom

Chair: – Univ. of Pittsburgh

Chair: – Gene Lay Inst. of Immunol. and Inflammation

Speaker: – Gene Lay Inst. of Immunol. and Inflammation

Speaker: – Johnson & Johnson

Speaker: – Albany Med. Col.

Speaker: – Univ. of Pittsburgh

Speaker: – Harvard Med. Sch.

Speaker: – HHMI, NYU Sch. of Med.

Speaker: – Cornell Univ.

Speaker: – Massachusetts Gen. Hosp.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

8:00 AM - 8:10 AM US ET

Introduction

Location: Ballroom

Speaker: – Gene Lay Inst. of Immunol. and Inflammation

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

8:10 AM - 8:41 AM US ET

IL-23 regulation of Th17 immune pathway in autoimmune inflammation

Location: Ballroom

Speaker: – Johnson & Johnson

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

8:41 AM - 9:12 AM US ET

Th17 influencers

Location: Ballroom

Speaker: – Cornell Univ.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

9:12 AM - 9:43 AM US ET

The immune cellular network defined by RORyt

Location: Ballroom

Speaker: – HHMI, NYU Sch. of Med.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

9:43 AM - 9:58 AM US ET

Dietary Iron Overload Rewires Regulatory T Cells into IL-17–Mediated Proinflammatory Effectors Aggravating Yersinia enterocolitica Infection

Location: Ballroom

Author: – Albany Med. Col.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

9:58 AM - 10:29 AM US ET

At the crossroads of IL-17 signaling: IL-17 signal transduction in autoimmunity and fungal infections

Location: Ballroom

Speaker: – Univ. of Pittsburgh

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

10:29 AM - 10:44 AM US ET

A unique subset of allergen specific T helper 2+17 tissue resident memory cells is established in a mouse model of allergic inflammation

Location: Ballroom

Author: – Massachusetts Gen. Hosp.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

10:44 AM - 11:15 AM US ET

Unexpected roles of interleukin‑17 and identification of its target cells

Location: Ballroom

Speaker: – Harvard Med. Sch.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

9:15 AM - 9:45 AM US ET

A human tonsil organoid platform to model TLR-driven B cell differentiation and heterogeneity in SLE

Location: 153AB

Speaker: – Boston Children's Hospital

9:15 AM - 11:15 AM US ET

TI5 - Modeling the Human Immune Response, Sponsored by AAI Clin. Immunol. Comm.

Location: 153AB

Chair: – Cabaletta Bio

Chair: – Cleveland Clinic

Speaker: – Boston Children's Hospital

Speaker: – Massachusetts General Hospital/Harvard Medical School

Speaker: – Augusta University

10:15 AM - 10:45 AM US ET

Modeling disease-driving human immune responses with AI

Location: 153AB

Speaker: – Augusta University

9:15 AM - 11:15 AM US ET

CAREER/NET21 - Professions in Biotech: Panel Discussion and Networking (ticketed event), Sponsored by the AAI Edu. Comm.

Location: 258AB

Chair: – Biogen

Panelist: – Promega Corp.

Panelist: – Moderna

Panelist: – Cytek Biosciences

Panelist: – Uniquity Bio

Career/Networking (CAREER/NET)

9:30 AM - 10:15 AM US ET

EXW25 - Small Molecule Drug Discovery utilizing a Multiplex Cytokine Detection Platform

Location: Exhibitor Workshop Room 1

Speaker: – Expedition Medicines

9:30 AM - 5:30 PM US ET

CAREER/NET20 - NIH Resource Room

Location: 150

Career/Networking (CAREER/NET)

9:45 AM - 10:15 AM US ET

Optimizing structural biology for improved human antibody effectiveness: pharmacology and mathematical modeling to achieve better clinical outcomes; from autoimmunity to cancer

Location: 153AB

Speaker: – Massachusetts General Hospital/Harvard Medical School

9:45 AM - 11:15 AM US ET

TI6 - A New Era in Interdisciplinary Immunotherapy, Sponsored by the Chinese Soc. for Immunol. (CSI)

Location: 153C

Chair: – Shanghai Medical College, Fudan University

Chair:

Speaker: – Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College; Chinese Society for Immunology

Speaker: – Institute of Immunology, Zhejiang University School of Medicine

Speaker: – Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Speaker: – Department of Immunology, School of Basic Medical Sciences, Fudan University

Speaker: – Changping Laboratory

9:45 AM - 10:03 AM US ET

Mechanical softness: paving the road of CAR T therapy

Location: 153C

Speaker: – Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College; Chinese Society for Immunology

10:03 AM - 10:21 AM US ET

Lactate modulation of macrophage function in inflammation and resolution

Location: 153C

Speaker: – Institute of Immunology, Zhejiang University School of Medicine

10:21 AM - 10:39 AM US ET

Novel Dendritic Cell-Driven Pathways in Skin Inflammation: Targeting Neuro-Immune Crosstalk in Vitiligo and Relapse-Prone Cells in Psoriasis

Location: 153C

Speaker: – Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

10:39 AM - 10:57 AM US ET

Interdisciplinary design of NK-based immunotherapies

Location: 153C

Speaker: – Department of Immunology, School of Basic Medical Sciences, Fudan University

10:57 AM - 11:15 AM US ET

T-cell Signaling and Engineering

Location: 153C

Speaker: – Changping Laboratory

9:45 AM - 11:15 AM US ET

HUM5 - Animal Models and Multi-omics Technology

Location: 102

Moderator: – Washington Univ. Sch. of Med., St. Louis

Moderator: – Columbia University

9:45 AM - 10:00 AM US ET

KRAS G12D Blocks Erythroid Differentiation and Promotes Inflammatory Pathways at the Single Cell Level in Myeloid Malignancies

Location: 102

Author: – Albert Einstein Col. of Med.

Immune Mechanisms of Human Disease (HUM)

10:00 AM - 10:15 AM US ET

Cooperative molecular mimicry drives prolonged autoinflammation in multisystem inflammatory syndrome in children

Location: 102

Author: – Columbia University

Immune Mechanisms of Human Disease (HUM)

10:15 AM - 10:30 AM US ET

Unmasking the in vivo role of IGF1R in Chronic lymphocytic leukemia and identifying novel inhibitors for its function

Location: 102

Author: – University Hospital Ulm

Immune Mechanisms of Human Disease (HUM)

10:30 AM - 10:45 AM US ET

Single-cell blood immune cell atlas of immune diseases

Location: 102

Author: – Korea Advanced Inst. of Sci.and Technol.

Immune Mechanisms of Human Disease (HUM)

10:45 AM - 11:00 AM US ET

Discovering Shared Mechanisms of Autoimmunity using Omics Technologies

Location: 102

Author: – Massachusetts Gen. Hosp., Harvard Med. Sch.

Immune Mechanisms of Human Disease (HUM)

11:00 AM - 11:15 AM US ET

Neutrophil–endothelial crosstalk after skin UV exposure orchestrates renal repair in health but drives profibrotic remodeling in lupus

Location: 102

Author: – Geisel Sch. of Med. at Dartmouth

Immune Mechanisms of Human Disease (HUM)

9:45 AM - 11:15 AM US ET

HUM4 - Complement - Key Modulator of Tissue Autoimmunity and Inflammation, Sponsored by the Intl. Complement Soc. (ICS)

Location: 104C

Chair: – NHLBI

Chair: – NIDDK

Speaker: – Oxford University, UK

Speaker: – Krembil Brain Institute and University of Toronto

Speaker: – Washington Univ., St. Louis

Speaker: – Northwestern Univ Feinberg School of Medicine

9:45 AM - 11:15 AM US ET

Complement and immunosuppressive tumour microenvironments

Location: 104C

Speaker: – Oxford University, UK

9:45 AM - 11:15 AM US ET

Complement as Driver of Age-dependent Progression: Insights from Multiple Sclerosis and a Mouse Model

Location: 104C

Speaker: – Krembil Brain Institute and University of Toronto

9:45 AM - 11:15 AM US ET

Complement therapeutics in organ transplantation: Current approaches and future directions

Location: 104C

Speaker: – Northwestern Univ Feinberg School of Medicine

9:45 AM - 11:15 AM US ET

Local Complement as a Tissue Sentinel: Microbiota-Driven Immunity at Mucosal Barriers

Location: 104C

Speaker: – Washington Univ., St. Louis

9:45 AM - 11:15 AM US ET

HYP2 - Immediate Hypersensitivity

Location: 151

Moderator: – Loyola University Chicago

Moderator: – Virginia Commonwealth University

10:00 AM - 10:15 AM US ET

Germline-encoded recognition underlies development of convergent antibodies in humans

Location: 151

Author: – Massachusetts Gen. Hosp./Harvard Medical School

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

9:45 AM - 10:00 AM US ET

BCR Density Regulates IgE Germinal Center B Cell Survival

Location: 151

Author: – Brigham and Women’s Hospital and Harvard Medical School

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

10:15 AM - 10:30 AM US ET

Epitope-Specific Neutralizing IgG4 Antibodies Define Natural and Acquired Tolerance in Peanut Allergy

Location: 151

Author: – Massachusetts Gen. Hosp., Harvard Med. Sch.

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

10:30 AM - 10:45 AM US ET

Inhibition of Glutamine metabolism is essential in decreasing the hallmarks of Atopic Dermatitis pathogenesis.

Location: 151

Author: – Virginia Commonwealth Univ. Sch. of Med.

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

10:45 AM - 11:00 AM US ET

The Epstein-Barr virus-induced gene 2–Cholesterol 25-hydroxylase axis is essential for the recruitment of mast cell progenitors.

Location: 151

Author: – Harvard Med. Sch.

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

11:00 AM - 11:15 AM US ET

IL-33-mediated Mast Cell Function is Female Dominant

Location: 151

Author: – Virginia Commonwealth Univ.

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

9:45 AM - 11:15 AM US ET

TIME6 - Immune Cells in the Tumor Microenvironment I

Location: 156

Moderator: – Vanderbilt University Medical Center

Moderator: – National Institute on Aging, National Institutes of Health

9:45 AM - 10:00 AM US ET

T cell adaption to bile acids is critical for their responses during liver tumors.

Location: 156

Author: – UMass Chan Med. Sch.

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

10:00 AM - 10:15 AM US ET

GSDME-Mediated Pyroptosis Suppresses Anti-Tumor Immunity via IL-1α–Dependent Recruitment of Immunosuppressive Myeloid Cells

Location: 156

Author: – Natl. Univ. of Singapore

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

10:15 AM - 10:30 AM US ET

Targeting Pros1 to improve chemotherapy efficacy and immune anti-tumor response

Location: 156

Author: – University of Kentucky

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

10:30 AM - 10:45 AM US ET

Exocyst complex regulates fungal-mediated IL-33 release and facilitates type 2 immune response

Location: 156

Author: – Roswell Park Comprehensive Cancer Center

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

9:45 AM - 11:15 AM US ET

NEUR3 - Immunity at CNS Barriers and Borders

Location: 104AB

Moderator: – Mayo Clinic

Moderator: – National Institute of Neurological Disorders and Stroke, National Institutes of Health

9:45 AM - 9:57 AM US ET

Microbially Induced CD8⁺ Tissue-Resident Memory T Cells Rewire Microglial Function and Suppress Neurogenesis in the Brain

Location: 104AB

Author: – University of Iowa

Neuroimmunology (NEUR)

9:57 AM - 10:09 AM US ET

Tmem119+ microglia controls blood-brain barrier disruption through MHC class I restricted antigen presentation in a CNS vascular disease model

Location: 104AB

Author: – Mayo Clin., Minnesota

Neuroimmunology (NEUR)

10:09 AM - 10:21 AM US ET

ICAM-1 Adhesion Molecules Facilitate Immune Cell Docking at the Cribriform Plate Perineural Microenvironment in Aging

Location: 104AB

Author: – University of Wisconsin- Madison

Neuroimmunology (NEUR)

10:21 AM - 10:33 AM US ET

IL-11-induced NLRP3 inflammasome activation mediates pyroptotic cell death in human neurons

Location: 104AB

Author: – Thomas Jefferson Univ.

Neuroimmunology (NEUR)

10:33 AM - 10:45 AM US ET

Vessel-Associated Microglia Maintain Vascular Integrity and Prevent Early Hemorrhage in Brain Tumors

Location: 104AB

Author: – University of Texas Health Science Center, Houston, McGovern Medical School

Neuroimmunology (NEUR)

10:45 AM - 10:57 AM US ET

Highly dynamic dural sinuses support meningeal immunity

Location: 104AB

Author: – National Institute of Neurological Disorders and Stroke, National Institutes of Health

Neuroimmunology (NEUR)

10:57 AM - 11:09 AM US ET

Microglial Remodeling of Cerebrovascular Structure and Function during Respiratory Inflammation

Location: 104AB

Author: – University of Virginia

Neuroimmunology (NEUR)

9:45 AM - 11:15 AM US ET

VAC5 - Mechanistic Insights into Determinants of Vaccine Immunogenicity

Location: 157

Moderator: – Duke University

Moderator: – University of Michigan

9:45 AM - 10:00 AM US ET

The Immune Signatures Data Resource 2.0: An Expanded Compendium of Systems Vaccinology Datasets

Location: 157

Author: – Yale School of Medicine

Vaccines and Immunotherapy (VAC)

10:00 AM - 10:15 AM US ET

In vitro modeling for the in-depth characterization of mRNA vaccines

Location: 157

Author: – Sanofi US

Vaccines and Immunotherapy (VAC)

10:15 AM - 10:30 AM US ET

Clinical correlates of maternal antibody interference with oral rotavirus vaccine immunogenicity

Location: 157

Author: – Cornell University

Vaccines and Immunotherapy (VAC)

10:30 AM - 10:45 AM US ET

Human Spleen Organoids as a Preclinical Platform for Evaluating Vaccine-Induced Antibody Responses

Location: 157

Author: – Stanford Univ.

Vaccines and Immunotherapy (VAC)

10:45 AM - 11:00 AM US ET

Distinct Inflammatory Programs Underlie the Intramuscular Lipid Nanoparticle Response

Location: 157

Author: – University of Vermont

Vaccines and Immunotherapy (VAC)

11:00 AM - 11:15 AM US ET

Vaccine-induced Immunometabolic Reprogramming in Neonates from The Gambia and Papua New Guinea

Location: 157

Author: – Harvard Medical School, Boston Children's Hospital

Vaccines and Immunotherapy (VAC)

10:30 AM - 10:55 AM US ET

BOOTH7 - Five Things You Should Know About Advocacy, Sponsored by the Comm. on Public Affairs

Location: AAI Booth Theater, Booth 731

Speaker: – AAI

10:30 AM - 12:30 PM US ET

AAI Veterinary Immunology Committee Meeting (by invitation only)

Location: 154

11:00 AM - 11:30 AM US ET

BOOTH8 - Why Talk About Science? Creating a Culture Where Communication Thrives, Sponsored by the AAI Public Communications Comm.

Location: AAI Booth Theater, Booth 731

Speaker:

11:45 AM - 12:15 PM US ET

CAREER/NET22 - Guided Poster Walk

Location: Hall A

Career/Networking (CAREER/NET)

12:30 PM - 2:30 PM US ET

BA5 - Autoimmunity, Neurodegeneration and Aging

Location: 104C

Chair: – NIA/NIH

Chair: – Washington Univ. School of Medicine

12:30 PM - 2:30 PM US ET

Autoimmune Dysfunction in FTD-ALS Spectrum Disease

Location: 104C

Speaker: – Washington Univ. School of Medicine

12:30 PM - 2:30 PM US ET

Age Dependent Immune Remodeling as a Driver of Autoimmune Disease

Location: 104C

Speaker: – Mayo Clinic

12:30 PM - 2:30 PM US ET

Is Alzheimer’s Disease an Autoimmune Disorder of Innate Immunity

Location: 104C

Speaker: – Univ. of Toronto

12:30 PM - 2:30 PM US ET

Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson’s Disease

Location: 104C

Speaker: – Yale Univ.

12:30 PM - 2:30 PM US ET

Harnessing Neuroimmune Interactions for Disease Modification in Alzheimer’s & Parkinson’s

Location: 104C

Speaker: – Indiana University School of Medicine

12:45 PM - 1:45 PM US ET

TI7 - Adaptive T cell immunity in infection, vaccination, and neurodegeneration

Location: 153C

Speaker: – La Jolla Inst. for Immunol

Translational and Interventional Immunology (TI)

12:45 PM - 1:45 PM US ET

TI7 - AAI-Steinman Award for Human Immunology Research Presentation and Lecture, generously supported by BioLegend from Revvity

Location: 153C

Chair: – Univ. of Washington

Speaker: – La Jolla Inst. for Immunol

12:45 PM - 2:15 PM US ET

COMP6 - Computational Tool Development

Location: 102

Moderator: – Vanderbilt University Medical Center

12:45 PM - 1:00 PM US ET

Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP

Location: 102

Author: – Tufts University

Computational and Systems Immunology (COMP)

1:00 PM - 1:15 PM US ET

TIDEPOOL, a method for inferring disease trajectories across cohorts, identifies neutrophil-driven trajectories associated with severity of infections

Location: 102

Author: – Stanford Univ.

Computational and Systems Immunology (COMP)

1:15 PM - 1:30 PM US ET

Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

Location: 102

Author: – Univ. of Vermont Larner Col. of Med.

Computational and Systems Immunology (COMP)

1:30 PM - 1:45 PM US ET

TyCHE enables time-resolved lineage tracing of B cells in primary and recall germinal center reactions

Location: 102

Author: – Geisel School of Medicine at Dartmouth

Computational and Systems Immunology (COMP)

1:45 PM - 2:00 PM US ET

ImmPort: An AI Eco-System for Reproducible Immunology Research

Location: 102

Author: – Yale School of Medicine

Computational and Systems Immunology (COMP)

2:00 PM - 2:15 PM US ET

Characterizing spatial functional microniches with SpaceTravLR

Location: 102

Author: – University of Pittsburgh

Computational and Systems Immunology (COMP)

12:45 PM - 2:15 PM US ET

MUC6 - Emerging Topics in Mucosal Immunology

Location: 157

Moderator: – Washington University School of Medicine, St. Louis

Moderator: – University of Chicago

12:45 PM - 1:00 PM US ET

Sensory neuronal regulation of intestinal inflammation and immunity

Location: 157

Author: – Weill Cornell Med.

Mucosal And Regional Immunology (MUC)

1:00 PM - 1:15 PM US ET

Induction of germinal centers in human Peyer’s patches shapes robust intestinal adaptive immunity in early life.

Location: 157

Author: – Columbia Univ. Irving Med. Ctr.

Mucosal And Regional Immunology (MUC)

1:15 PM - 1:30 PM US ET

A single cell and spatially resolved atlas of the intestinal innate immune response to infection

Location: 157

Author: – Univ. of Pennsylvania

Mucosal And Regional Immunology (MUC)

1:30 PM - 1:45 PM US ET

Endobiotic glycolipid structure of gut symbionts modulates host inflammatory response

Location: 157

Author: – Harvard Medical School

Mucosal And Regional Immunology (MUC)

1:45 PM - 2:00 PM US ET

Breast milk-derived signals regulate epithelial cells maturation and gamma delta-IEL colonization to shape early life intestinal homeostasis

Location: 157

Author: – Brigham and Women’s Hospital, Harvard Medical School

Mucosal And Regional Immunology (MUC)

2:00 PM - 2:15 PM US ET

Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity

Location: 157

Author: – University of Vermont

Mucosal And Regional Immunology (MUC)

12:45 PM - 2:15 PM US ET

INC3 - Microenvironmental Influences on Innate Immunity

Location: 156

Moderator: – Boston Children's Hosp., Harvard Med. Sch.

12:45 PM - 1:00 PM US ET

Sepsis-induced alterations to the microenvironment promotes maladaptive emergency granulopoiesis and susceptibility to Streptococcus pneumoniae

Location: 156

Author: – Albany Med. Col.

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

1:00 PM - 1:15 PM US ET

High throughput CRISPR screens reveals novel roles for retroviral elements in proliferation and inflammation in murine macrophages

Location: 156

Author: – Univ. of California, Santa Cruz

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

1:15 PM - 1:30 PM US ET

Neutrophil diversity in the host defense niche

Location: 156

Author: – University of Calgary

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

1:30 PM - 1:45 PM US ET

Real-Time Single-Cell Kinetics of Innate Immune Activation

Location: 156

Author: – Wertheim Univ. of Florida Scripps Inst.

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

1:45 PM - 2:00 PM US ET

pH-Dependent Innate Immune Circuitry Confers Tolerance to Systemic Inflammation

Location: 156

Author: – Boston Children's Hosp., Harvard Med. Sch.

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

2:00 PM - 2:15 PM US ET

How do tissues sense proteolytic stress?

Location: 156

Author: – Yale University

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

12:45 PM - 2:15 PM US ET

TIPT4 - Molecular Mechanisms of Tumor Immunity

Location: 205

Moderator: – Johns Hopkins Univ. Sch. of Med.

Moderator: – Fred Hutchinson Cancer Res. Ctr.

12:45 PM - 1:00 PM US ET

Extracellular cAMP as a potent immune modulator promotes T cell exhaustion in chronic lymphocytic leukemia

Location: 205

Author: – University of Alberta

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

1:00 PM - 1:15 PM US ET

Identification of a FoxP3-specific small molecule degrader with potent antitumor immunotherapeutic efficacy

Location: 205

Author: – Northwestern University

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

1:15 PM - 1:30 PM US ET

Immunological targeting of the endogenous retroviral protein ERVMER34-1 in carcinomas promotes epitope spread and enhances response to PD-L1 blockade

Location: 205

Author: – National Cancer Institute, Center for Cancer Research, National Institutes of Health

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

1:30 PM - 1:45 PM US ET

A universal CD4 epitope enhances cytotoxic T-cell priming and memory in glioblastoma peptide vaccination

Location: 205

Author: – Duke University School of Medicine

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

1:45 PM - 2:00 PM US ET

Mouse EL4 lymphoma strains differentially respond to a loss of BCATc from T cells and αCTLA4 immunotherapy

Location: 205

Author: – Des Moines University

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

2:00 PM - 2:15 PM US ET

The role of the transcription factor Blimp-1 in T cells in anti-PD1 immunotherapy in non-small cell lung cancer

Location: 205

Author: – University Hospital Erlangen

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

12:45 PM - 2:15 PM US ET

CCR2 - Pathophysiology of cytokines and chemokines

Location: 153AB

12:45 PM - 12:57 PM US ET

Fractalkine/CX3CL1 Functions as a Transmembrane Receptor to Promote Transendothelial Migration through glycan-dependent condensation

Location: 153AB

Author: – Yale School of Medicine

Cytokines and Chemokines and their Receptors (CCR)

12:57 PM - 1:09 PM US ET

CCL20-CCR6 signaling modifies cellular metabolism in CD4 T cells and drives the differentiation of pathogenic Th17 cells

Location: 153AB

Author: – BRIC-National Centre for Cell Science

Cytokines and Chemokines and their Receptors (CCR)

1:09 PM - 1:21 PM US ET

Wild-Derived Microbiota Protect Against Diet-Induced Obesity via an Immune-Mediated Effect on Brown Adipocytes

Location: 153AB

Author: – National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

Cytokines and Chemokines and their Receptors (CCR)

1:21 PM - 1:33 PM US ET

Anatomic compartmentalization of a cytokine buffer system promotes anti-viral immune defense

Location: 153AB

Author: – Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University

Cytokines and Chemokines and their Receptors (CCR)

1:33 PM - 1:45 PM US ET

Targeting IL-22 activity to the gut epithelium confers disease benefit without provoking skin inflammation

Location: 153AB

Author: – Ampersand Biomedicines

Cytokines and Chemokines and their Receptors (CCR)

1:45 PM - 1:57 PM US ET

Signaling pathways via BAFF receptor/Nav1.7 channel contribute to the activation of monocytes and B cells in patients with Sjögren’s disease.

Location: 153AB

Author: – Keio University School of Medicine

Cytokines and Chemokines and their Receptors (CCR)

1:57 PM - 2:09 PM US ET

IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection

Location: 153AB

Author: – Brown Univ.

Cytokines and Chemokines and their Receptors (CCR)

12:45 PM - 2:15 PM US ET

NEUR4 - Peripheral & Central Neuroimmune Interactions

Location: 253

Moderator: – Queen's University

Moderator: – Duke University

12:45 PM - 1:00 PM US ET

Systemic CXCL13 as a possible sex-dependent biomarker to identify neuroinflammation in subclinical food allergies

Location: 253

Author: – Univ. of North Dakota

Neuroimmunology (NEUR)

1:00 PM - 1:15 PM US ET

In Vivo Dynamics of Memory CD8⁺ T Cell Activation Using a Fluorescent Timer Protein of TCR Signaling

Location: 253

Author: – Mayo Clin., Minnesota

Neuroimmunology (NEUR)

1:15 PM - 1:30 PM US ET

Oxysterol-Mediated Modulation of NFB -Linked Systemic Inflammatory Response in a Neonatal Mouse Model of Intestinal Perforation

Location: 253

Author: – Duke Univ. Sch. of Med.

Neuroimmunology (NEUR)

1:30 PM - 1:45 PM US ET

Double positive (DP) developing thymocytes regulate the development of neuronal cell bodies within the thymus

Location: 253

Author: – Duke University

Neuroimmunology (NEUR)

1:45 PM - 2:00 PM US ET

Adrenergic Signalling Drives Accumulation of Myeloid-derived Suppressor Cells in the Liver During Stress

Location: 253

Author: – Univ. of Western Ontario

Neuroimmunology (NEUR)

2:00 PM - 2:15 PM US ET

Kupffer cell identity, phenotype, and function rely on continual hepatic sympathetic nerve output

Location: 253

Author: – University of Calgary Cumming School of Medicine

Neuroimmunology (NEUR)

12:45 PM - 2:15 PM US ET

LYM11 - Regulating Adaptive Responses

Location: 104AB

Moderator: – Texas A&M University Health Science Center

12:45 PM - 1:00 PM US ET

CD96 as a target to reverse aryl hydrocarbon receptor mediated immune suppression in aged individuals

Location: 104AB

Author: – Dana Farber Cancer Institute

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

1:00 PM - 1:15 PM US ET

Acetyl-CoA generation by Acly distinctly regulates CD4 T cell programming during Plasmodium infection

Location: 104AB

Author: – University of Iowa

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

1:15 PM - 1:30 PM US ET

Functionally divergent resident memory T cells localize to lung and lymph node following influenza infection

Location: 104AB

Author: – MIT

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

1:30 PM - 1:45 PM US ET

MHC-II-restricted neoantigen expression drives tumor infiltration, activation, and maintenance of nonspecific T cells in lung cancer

Location: 104AB

Author: – Koch Inst. for Integrative Cancer Res., MIT

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

1:45 PM - 2:00 PM US ET

Tissue-directed maintenance of human B-cell memory after vaccination and infection

Location: 104AB

Author: – Columbia Univ. Irving Med. Ctr.

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2:00 PM - 2:15 PM US ET

Quantify the age-related decline of CD8⁺ T cell response to a novel antigen

Location: 104AB

Author: – National Institutes of Health

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

12:45 PM - 2:15 PM US ET

TECH2 - Technical Innovations for Therapies

Location: 151

Moderator: – Boston Children's Hospital/Harvard

Moderator: – Beckman

12:45 PM - 1:00 PM US ET

Goal-oriented transgenic TCR-T cell design for efficient cancer immunotherapy

Location: 151

Author: – Thomas Jefferson University

Technological Innovations in Immunology (TECH)

1:00 PM - 1:15 PM US ET

Generation and Performance of a DNA Barcode-Based Nuclear Receptor Reporter Library

Location: 151

Author: – Dartmouth Col.

Technological Innovations in Immunology (TECH)

1:15 PM - 1:30 PM US ET

Development of an in vitro Sjögren’s disease tissue chip for mechanistic studies and drug screening

Location: 151

Author: – University of Rochester

Technological Innovations in Immunology (TECH)

1:30 PM - 1:45 PM US ET

A High-Throughput, Systems-based Neutralizing Antibody Assay Identifies Humoral Features Linked with Compartmentalized Neutralization

Location: 151

Author: – Harvard Univ. Chan Sch. of Pub. Hlth.

Technological Innovations in Immunology (TECH)

1:45 PM - 2:00 PM US ET

High-throughput TCR-epitope screening using the Jurkat NFAT Reporter-K562 APC cell system on the Microwell ELISpot Platform

Location: 151

Author: – Cellecta

Technological Innovations in Immunology (TECH)

2:00 PM - 2:15 PM US ET

Multi-omics profiling with InTraSeq™ uncovers novel single-cell RNA and Proteomics events in CARTs

Location: 151

Author: – Cell Signaling Technology

Technological Innovations in Immunology (TECH)

1:00 PM - 1:45 PM US ET

CAREER/NET23 - Connect with Me Networking

Location: Hall A

Career/Networking (CAREER/NET)

1:00 PM - 2:00 PM US ET

AAI Membership Committee Meeting (invitation only)

Location: 154

2:45 PM - 3:15 PM US ET

BOOTH9 - AAI Education: Recommended Immunology Learning Objectives for MedEd, Sponsored by the AAI Edu. Comm.

Location: AAI Booth Theater, Booth 731

3:45 PM - 5:45 PM US ET

CAM4 - President's Symposium: Going Places: The Multi-Step Adhesion Cascade - 35 Years and Counting

Location: Ballroom

Speaker: – Stanford Sch. of Med.

Speaker: – Boston Children's Hospital, Harvard Medical School

Speaker: – ETH Zurich

Speaker: – Queen's University

Cellular Adhesion, Migration, and Inflammation (CAM)

3:45 PM - 3:53 PM US ET

CAM4 - AAI Excellence in Mentoring Award Presentation, Olivera J. Finn, Univ. of Pittsburgh Sch. of Med., USA

Location: Ballroom

3:53 PM - 4:21 PM US ET

CAM4 - The many steps to an understanding of leukocyte homing

Location: Ballroom

Speaker: – Stanford Sch. of Med.

Cellular Adhesion, Migration, and Inflammation (CAM)

4:21 PM - 4:49 PM US ET

CAM4 - Integrin agonists: new tools for organoids

Location: Ballroom

Speaker: – Boston Children's Hospital, Harvard Medical School

Cellular Adhesion, Migration, and Inflammation (CAM)

4:49 PM - 5:15 PM US ET

CAM4 - Linking T cell differentiation and trafficking

Location: Ballroom

Speaker: – ETH Zurich

Cellular Adhesion, Migration, and Inflammation (CAM)

5:17 PM - 5:45 PM US ET

CAM4 - Recruitment of immune cells from vascular and avascular sites to altered tissues

Location: Ballroom

Speaker: – Queen's University

Cellular Adhesion, Migration, and Inflammation (CAM)

6:00 PM - 6:45 PM US ET

IRM6 - Counting to 9: the amazing adventures of the 9th interleukin

Location: Ballroom

Speaker: – Indiana Univ. Sch. of Med.

7:30 PM - 10:00 PM US ET

IMMUNOLOGY2026™ Gala (ticketed event), generously supported by BioLegend from Revvity

Location: Moakley Courthouse - offsite

Spon by BioLegend from Revvity